10 Best sinus medicines of 2025

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Best Choice

1

GenCare
GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

25% Off
Main highlights

Maximum Strength Relief
10 mg Phenylephrine HCl provides strong sinus and nasal congestion relief.

Ideal for Chronic Congestion
Perfect for families or individuals with frequent allergy symptoms.

Highly Praised Value
Customers appreciate the affordability and effectiveness compared to other brands.
9.7

Exceptional

Our Rating

9.7
worth the money

9.5
dispense easily

9.3
simple to consume
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Value for Money

2

Vicks
Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

14% Off
Main highlights

12-Hour Relief from Congestion
Provides instant, long-lasting relief from nasal congestion and sinus pressure for up to 12 hours.

Ideal for Cold and Allergy Season
Perfect for treating severe sinus congestion and pressure from colds or allergies.

Instant Effectiveness Praised by Users
Highly rated for its immediate effectiveness in clearing nasal passages.
9.5

Excellent

Our Rating

9.5
Simple to use

9.3
Moisturizing

9.1
worth the money
3

Mucinex
Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

21% Off
Main highlights

Maximum Strength Relief
Provides relief from pain, headache, nasal, sinus, and chest congestion.

Ideal for Severe Congestion
Best for adults experiencing severe sinus and nasal congestion.

Praised for Effectiveness
Customers appreciate the product's good results despite small packaging.
9.4

Excellent

Our Rating
4

Sudafed
Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

25% Off
Main highlights

Fast Powerful Relief
Provides maximum strength, non-drowsy relief for sinus congestion and pain.

Ideal for Allergy Season
Perfect for relieving nasal congestion from allergies and colds.

Customer Praised Effectiveness
Highly rated for its effective relief during allergy season.
9.3

Excellent

Our Rating

9.1
simple to consume

8.4
worth the money

8.0
Comfort
5

Tylenol
Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

26% Off
Main highlights

Non-Drowsy Sinus Relief
Provides non-drowsy relief from sinus congestion, headaches, and pressure with acetaminophen and phenylephrine HCl.

Ideal for Daytime Use
Perfect for adults and children 12+ needing effective daytime sinus and headache relief.

High Quality Effectiveness
Praised for superior effectiveness compared to generic brands, ensuring reliable symptom relief.
9.0

Excellent

Our Rating

9.5
simple to consume

9.5
worth the money

9.1
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6

Tylenol
Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

28% Off
Main highlights

Non-Drowsy Symptom Relief
Provides non-drowsy relief from sinus headache, nasal congestion, and chest congestion.

Daytime Use for Adults and Teens
Ideal for adults and children 12+ needing daytime sinus relief.

Quick Decongestion Effect
Customers praise its fast-acting decongestion for stuffy head relief.
8.7

Very Good

Our Rating
7

Vicks
Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps
Main highlights

Fast Relief for Sinus Symptoms
Experience quick relief from nasal congestion, sinus pressure, and headaches.

Ideal for Cold and Allergy Symptoms
Best for sinus issues from colds, hay fever, or allergies.

Praised for Effectiveness
Customers frequently praise its effectiveness in relieving sinus discomfort.
8.6

Very Good

Our Rating
8

Sudafed
Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

26% Off
Main highlights

Powerful Sinus Relief
20-count of maximum strength tablets for day and night sinus congestion relief.

Best for All-Day Use
Ideal for relieving sinus pressure and congestion both day and night.

Fast Symptom Relief
Customers praise quick relief from sinus congestion and pressure.
8.5

Good

Our Rating

9.5
simple to consume

8.7
worth the money

8.4
pain management
9

Benadryl
Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct

19% Off
Main highlights

Comprehensive Allergy and Congestion Relief
Combines diphenhydramine and phenylephrine for effective allergy and congestion relief in one tablet.

Ideal for Allergy and Cold Symptoms
Perfect for relieving symptoms from hay fever, indoor/outdoor allergies, and common cold.

Praised for Itch Relief
Highly recommended for its effectiveness in alleviating itching.
8.3

Good

Our Rating
10

Sudafed
Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct

20% Off
Main highlights

Comprehensive Relief
Provides non-drowsy relief from sinus pain, pressure, and congestion with acetaminophen, phenylephrine HCl, and guaifenesin.

Ideal for Cold and Allergy Symptoms
Perfect for alleviating symptoms of hay fever, upper respiratory allergies, and the common cold.

Highly Effective for Stuffy Nose
Praised for its effectiveness in relieving stuffy noses, according to customer reviews.
8.2

Good

Our Rating

9.9
simple to consume

9.7
pain management

8.0
For Gentle skin

10 Best sinus medicines of 2025

1

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

9.7

9.5

9.3

How do we rank?

How do we rank?

Analyzing top stores

2

Vicks Sinex SEVERE Nasal Spray, Original Ultra Fine Mist, Decongestant Medicine, Relief from Stuffy Nose due to Cold or Allergy, & Nasal Congestion, Sinus Pressure Relief, 265 Sprays x 2

9.5

9.3

9.1

3

Mucinex Sinus Max Severe Congestion & Pain Relief, Maximum Strength Nasal & Sinus Relief, Decongestant for Adults, Acetaminophen Pain Reliever, Guaifenesin Expectorant and Mucus Removal, 20 Caplets

4

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

9.1

8.4

8.0

5

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

9.5

9.5

9.1

6

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

7

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

8

Sudafed PE Sinus Congestion Day + Night Maximum Strength Decongestant & Antihistamine Tablets with Phenylephrine HCl & Diphenhydramine HCl, Helps Nasal & Sinus Pressure & Congestion, 20 ct

9.5

8.7

8.4

9

Benadryl Allergy Plus Congestion Ultratabs with Diphenhydramine HCl Antihistamine & Phenylephrine HCl Nasal Decongestant, Allergy & Sinus Congestion Relief Tablets, 24 ct

10

Sudafed PE Head Congestion + Mucus Tablets for Sinus Pressure, Pain & Congestion, 24 ct

9.9

9.7

8.0

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